Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. Although ESRD may be the most recognizable consequence of diabetic kidney disease, the majority of patients actually die from cardiovascular diseases and infections before needing kidney replacement therapy. The natural history of diabetic kidney disease includes glomerular hyperfiltration, progressive albuminuria, declining GFR, and ultimately, ESRD. Metabolic changes associated with diabetes lead to glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Despite current therapies, there is a large residual risk of diabetic kidney disease onset and progression. Therefore, widespread innovation is urgently needed to improve health outcomes for patients with diabetic kidney disease.

Achieving this goal will require the characterization of new biomarkers, designing clinical trials that evaluate clinically pertinent endpoints, and the development of therapeutic agents targeting kidney-specific disease mechanisms (e.g., glomerular hyperfiltration, inflammation, and fibrosis). Additionally, greater attention to the dissemination and implementation of best practices is needed in both clinical and community settings. Dr. Gaikwad Diabetes Center is having well-known Nephrologist in Bhosari.

Kidney disease attributed to diabetes is a major but under-recognized contributor to the global burden of disease. Between 1990 and 2012, the number of deaths attributed to DKD rose by 94%. This dramatic rise is one of the highest observed for all reported chronic diseases. Notably, most of the excess risk of all-cause and cardiovascular disease (CVD) mortality for patients with diabetes is related to the presence of DKD. Dr. Gaikwad Diabetes Center has a team of specialist Nephrologist in Bhosari, Pune. We offer treatment for diabetic kidneys, glomerular hyperfiltration, progressive albuminuria, declining GFR, and ESRD.

Risk Factors

DKD risk factors can conceptually be classified as susceptibility factors (e.g., age, sex, race/ethnicity, and family history), initiation factors (e.g., hyperglycemia and AKI), and progression factors (e.g., hypertension, dietary factors, and obesity)

 Two of the most prominent established risk factors are hyperglycemia and hypertension.